Focused beam reflectance measurement (FBRM) to study microparticle preparation by the solvent evaporation method

Muhaimin, Muhaimin and Dickenhorst, Burkhard and Bodmeier, Roland (2013) Focused beam reflectance measurement (FBRM) to study microparticle preparation by the solvent evaporation method. In: Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, November, 10-11 2013, San Antonio, USA.

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Abstract

Purpose: To investigate the formation process of five different polymeric microparticles from oil-in-water emulsion using a focused beam reflectance measurement (FBRM). Methods: Polymeric microparticles were prepared by the solvent evaporation method (O/W) using various polymers, including ethyl cellulose 4 cp, Eudragit® RS 100, Eudragit® RL 100, PLGA (Resomer® RG503H) and poly(ε-caprolactone) (PCL). FBRM was used to monitor chord length distribution (CLD), solidification rate and chord count during the shift from emulsion droplets into solid microparticles during solvent evaporation. The morphology of polymeric microparticles was characterized by optical microscopy and scanning electron microscopy (SEM). Results: The transformation of the emulsion droplets into solid microparticles occured within the first 10.5, 19, 25, 30, and 55 minutes, when ethyl cellulose (EC), Eudragit® RS 100, Eudragit® RL 100, PLGA (RG503H) and PCL were used respectively. The square weighted mean chord lengths of polymeric microparticles were 83 µm (EC), 73 µm (Eudragit® RL 100), 64 µm (PLGA (RG503H)), 59 µm (Eudragit® RS 100) and 51 µm (PCL). The CLDs measured by FBRM showed that a larger particle size mean gave longer CLD and a reduced count rate due to the decreased number of microparticles. This phenomenon is not applicable to PCL. PCL produced the smallest particle size mean and smallest CLD, but not the highest chord count. It is due to the slight translucence of the PCL particles compared to the others. FBRM data are highly dependent on the optical properties of materials and opacity level of particles. Scanning electron microscopy (SEM) data revealed that the morphology of microparticles was influenced by type and physical properties of polymer. Conclusion: FBRM can be employed for online monitoring of the shift in the microparticle CLD and detect transformation of the emulsion droplets into solid microparticles during the solvent evaporation process. The microparticle CLD and transformation process was strongly influenced by polymer type. Key words: ethyl cellulose; Eudragit® RL 100; Eudragit® RS 100; PLGA (Resomer® RG503H); poly(ε-caprolactone); solvent; FBRM; microparticles; solvent evaporation method; chord length distribution

Type: Conference (Paper)
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: MUHAIMIN
Date Deposited: 23 Oct 2017 01:57
Last Modified: 23 Oct 2017 01:57
URI: http://repository.unja.ac.id/id/eprint/2316

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