Poly(lactic-co-glycolic acid) Microparticle Blends Containing Propranolol HCl and Carbamazepine: Effect of Dispersion Time Interval on Drug Release

Muhaimin, Muhaimin and Bodmeier, Roland (2014) Poly(lactic-co-glycolic acid) Microparticle Blends Containing Propranolol HCl and Carbamazepine: Effect of Dispersion Time Interval on Drug Release. In: Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, November 2-6, 2014, San Diego, USA.

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Abstract

Purpose: The purpose of this study was to investigate physicochemical properties of poly(lactic–co–glycolic acid) (PLGA RG502H) microparticle blends containing drugs with different solubilities (propranolol HCl and carbamazepine) which were prepared by subsequent emulsification in the same external aqueous phase. Methods: Microparticle blends were formulated by the solvent evaporation method with W/O/W emulsion for propranolol HCl and O/W emulsion for carbamazepine. The propranolol HCl emulsion (W/O) and carbamazepine oil phase were dispersed in an external aqueous phase, with dispersion time intervals (DTI) of 0 and 60 min. Morphology of microparticle blends was characterized by scanning electron microscopy (SEM). Particle size mean of emulsion droplets/hardened microparticles were monitored by focused beam reflectance measurement (FBRM). Encapsulation efficiency (EE) and in vitro drug release in phosphate buffer pH 7.4 were also investigated. Results: The microparticles were spherical and had two particle families. FBRM data showed that the size of microparticle blends prepared with DTI 60 min and stirring time of 4 hour was larger than those with DTI 0 min. The encapsulation efficiency as microparticle blends were approx. 70% for propranolol HCl and 85 to 90 % for carbamazepine. Drug release in phosphate buffer after 28 d showed that propranolol HCl release was slower than carbamazepine from microparticle blends with DTI 60 min. While, propranolol HCl release from microparticle blends with DTI 0 min and microparticle containing propranolol as single drug was faster than carbamazepine release. This phenomenon was attributed to the interaction of the oil phase (carbamazepine) with already hardened particles from the primary emulsion (propranolol HCl). Conclusion: Propranolol HCl and carbamazepine release from microparticle blends using poly(lactic–co–glycolic acid) (PLGA RG502H) were strongly influenced by dispersion time interval (DTI) between propranolol HCl emulsion (W/O) and carbamazepine oil phase into an external aqueous phase. Key words: Microparticle blends, propranolol HCl, carbamazepine, poly(lactic-co-glycolic acid) (PLGA RG502H), FBRM, solvent evaporation method

Type: Conference (Paper)
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: MUHAIMIN
Date Deposited: 23 Oct 2017 01:59
Last Modified: 23 Oct 2017 01:59
URI: http://repository.unja.ac.id/id/eprint/2317

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