GSK-3b inhibitory activities of novel dichroloresorcinol derivatives from Cosmospora vilior isolated from a mangrove plant

Shiono, Yoshihito and Miyazaki, Nozomi and Murayama, Tetsuya and Koseki, Takuya and Harizon, Harizon and Gede Katja, Dewa and Supratman, Unang and Nakata, Juri and Kakihara, Yoshito and Saeki, Makio and Yoshida, Jun and Uesugi, Shota and Kimura, Ken-ichi (2016) GSK-3b inhibitory activities of novel dichroloresorcinol derivatives from Cosmospora vilior isolated from a mangrove plant. Phytochemistry Letters. pp. 122-127.

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Abstract

Cosmochlorins A (1), B (2), and C (3) were isolated from the endophytic fungus Cosmospora vilior IM2-155. The structures of 1, 2, and 3 were elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HRESITOFMS, and chemical reactions. Compounds 1, 2, and 3 were evaluated for their biological activity. Compounds 1 and 2 partially restored the growth inhibition caused by hyperactivated Ca2+-signaling in mutant yeast and showed glycogen synthase kinase (GSK)-3b inhibition activity at IC50 values of 62.5 and 60.6mM, respectively. Further, compound 2 significantly increased osteoclast formation by more than 1.5-fold in RAW264.7 cells compared to receptor activator of nuclear factor-kB ligand (RANKL) alone.

Type: Article
Subjects: Q Science > QD Chemistry
Depositing User: Elisa Edi
Date Deposited: 14 Sep 2017 02:11
Last Modified: 14 Sep 2017 02:11
URI: http://repository.unja.ac.id/id/eprint/987

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