Hasil Peer Review Publikasi : Efek Salep Ekstrak Pinang terhadap Level Fibroblast dan Kolagen pada Proses Penyembuhan Luka

olivia, ave and humaryanto, humaryanto (2019) Hasil Peer Review Publikasi : Efek Salep Ekstrak Pinang terhadap Level Fibroblast dan Kolagen pada Proses Penyembuhan Luka. jambi medical journal.

Text kreview karya ilmiah jurnal ilmiah efek salep ekstrak pinang terhadap level fibroblast dan kolagen pada proses penymbuhan luka.pdf Download (1MB)

Abstract

Background: Some plants, such as betel nuts (Areca catechu), is used as traditional antiseptic. Betel nut mash is applied on ulcus wound. Fibroblast and collagen are important factor in wound healing. Research objective : this study is to determine the effect of betel nuts extract on fibroblast and collagen level in full thickness wound healing processs. Methodology: this study used male rats Sprague dawney that randomly divided into 3 groups. Groups I received no treatment, groups II and III received areca catechu extracts with concentration 15% and 30% respectively. There are 12 rats in each groups. The treatment is given every day without wound’s debridement. Incision were made full thickness with diameter size 1,5 cm, on right back skin was made by lidocain anesthesia subcutaneously. Wound area were measured every days. Termination of rats were done in day 7 and day 16 to histopathology assessment with Haematoxylin-Eosin stain for fibroblast and collagen level by semiqualitative score. Results: level of collagen were higher in group that received extract but level of fibroblast were lower than control group in histopathology of day 7th. Conclusion: Extract of betel nut increased level of collagen. Keyword : areca catechu, betel nuts, wound, fibroblast, collagen, histopathology

Type:	Other
Subjects:	A General Works > AI Indexes (General) Universitas Jambi (UNJA) > Fakultas Kedokteran dan Ilmu Kesehatan > A General Works > AI Indexes (General)
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Ilmu Keperawatan
Depositing User:	Humaryanto
Date Deposited:	26 Jun 2020 03:57
Last Modified:	26 Jun 2020 03:57
URI:	https://repository.unja.ac.id/id/eprint/12302

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