Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study

Herlambang, Herlamabang and Fitri, Amelia Dwi and Syauqy, Ahmad and Yuwono, Yuwono and Puspasari, Anggelia and Enis, Rina Nofri and Faried, Ahmad (2021) Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study. BMC Research Notes, 14 (1). ISSN 1756-0500

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Abstract

Abstract Objective: Calcitonin receptor-like receptor (CRLR) regulates vasoconstriction and dilatation; the expression increases during hypoxia via activation of hypoxia response element (HRE) in CRLR gene promoter region. Variant in HRE, as well short tandem repeat (STR) variants near HRE in CRLR alters the gene expression. This study focused on a case–control study to investigate the expression of genetic typing CLRL promoter variant in pregnant women with severe preeclampsia and normal pregnancies, we also tried to describe interesting fndings of the genetic expression in anemic patients in the severe preeclampsia group. Our aimed to observe the correlation of CRLR gene promoter variant and anemia in severe preeclampsia. Results: There was no nucleotide variant in HRE; CACA box prior to HRE varied in length (15–24); CACA box with length >20 was used as cut of point. Hb was lower in CACA box length ≥21 (10.33±1.57) vs.<21 (11.01±1.67; p=0.391). CACA box polymorphism and anemia were correlated in severe preeclampsia (p=0.005) OR 0.038 (CI 0.003–0.544); not in normal (p=0.069). Keywords: Preeclampsia, CRLR, CA repeat, HRE, CACA box polymorph, Gene promoter

Type:	Article
Subjects:	R Medicine > RG Gynecology and obstetrics
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Kedokteran
Depositing User:	Herlambang
Date Deposited:	22 Mar 2021 19:18
Last Modified:	22 Mar 2021 19:18
URI:	https://repository.unja.ac.id/id/eprint/18019

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