Potensi Ekstrak Kering Belut (Monopterus albus) pada Pengobatan Tukak Lambung

rahman, havizur and maharini, indri (2020) Potensi Ekstrak Kering Belut (Monopterus albus) pada Pengobatan Tukak Lambung. PHARMACY: Jurnal Farmasi Indonesia, 17 (1). pp. 98-107. ISSN 2579-910X

Text S3-Pharmacy-ekstrak belut pada pengobatan tukak lambung.pdf Download (797kB)

Abstract

Consumption of alcohol, the use of nonsteroidal anti-inflammatory drugs, and improper diets are the cause of the increase of peptic ulcer cases worldwide. Since the long-term use of synthetic drugs often causes undesirable effects, the treatment with the nature-origin ones with, which is believed to be safer, is desirable. Eel (Monopterus albus) is known to have high protein content, which is similar to the snakehead murrels. The therapeutic use of snakehead murrel for the treatment of burns, wounds in post-operative scars, and ulcers have been widely evaluated. The proteins and amino acids are considered as the bioactive compounds responsible for the biological activities of the snakehead murrel. The study design was the randomized block, employed five treatment groups of five rats each. The mean bleeding point of rats in the negative control, positive control, and the eel dry extracts in the doses of 100, 200, and 400 mg/kg groups were 7.6, 2.6, 4.2, 1, and 1, while the average pH of gastric fluid were 4.948, 5.182, 4.224, 2.888, and 4.890, respectively. The bleeding point of rats in the positive control and the eel dry extracts in the doses of 100, 200, and 400 mg/kg groups were statistically different from the negative control. There was no correlation between pH and the onset of bleeding point, and hence pH could not be used as a parameter for gastric ulceration. It can be concluded that the dry extract of eel at an optimum dose of 200 mg/kg showed a potential efficacy for the treatment of peptic ulcers.

Type:	Article
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Farmasi
Depositing User:	HAVIZUR RAHMAN
Date Deposited:	22 Mar 2021 19:35
Last Modified:	22 Mar 2021 19:35
URI:	https://repository.unja.ac.id/id/eprint/18066

Actions (login required)

View Item