Maharani, Citra and Herlambang, Herlambang and Syauqy, Ahmad and Harahap, Huntari (2020) MORPHOLOGICAL FEATURES OF THE PLACENTA IN PREECLAMPSIA. In: The 3rd Green Development International Conference 2020, 2-3 Oct 2020, Jambi, Indonesia. (Unpublished)
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MORPHOLOGICAL FEATURES OF THE PLACENTA IN PE; CITRA M ET AL.pdf Download (769kB) |
Abstract
Background Preeclampsia is a major cause of maternal and neonatal mortality and morbidity. Failure of trophoblast invasion results in impaired remodelling of the endometrial spiral arteries in the placenta leading to hypoxia. This hypoxic condition trigger oxidative stress on the placenta and cause maternal preeclampsia. Hypoxia cause histological changes in parenchymal and vascular placenta. This condition can be observed through microscopic images. Aim This study aim to observe morphology of the human placenta in preeclampsia. Methods This research was observational study. Preeclampsia was diagnosed by elevated blood pressure (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) after 20 weeks of gestation. Human placental tissues were collected from 22 subjects pregnant women with preeclampsia and 3 subjects pregnant women without pre-eclampsia as controls. Full thickness placental tissues were collected immediately after delivery and fixed by formaldehyde 10%. Slides from medial and lateral placental tissue sections were stained with Haematoxylin Eosin. Haematoxylin Eosin slides were made in Biomolecular Laboratory Faculty of Medicine and Health Sciences Universitas Jambi. Results All placental tissue samples from pregnant women with preeclampsia showed the presence of decidual arteriopathy, hypoplasia of the distal villi which was characterized by increased intervillous space, intra and intervillous fibrin deposition and increased syncytial knotting due to malperfusion of the maternal vessels. In pregnant women without preeclampsia, placental morphological disorders were not found. Conclusion The histopathological images of placental tissue in preeclampsia patients showed abnormal morphology of the placenta which indicates hypoxia due to inadequate remodelling of the spiral arteries.
| Type: | Conference (Speech) |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Fakultas Kedokteran dan Ilmu Kesehatan > Kedokteran |
| Depositing User: | CITRA MAHARANI |
| Date Deposited: | 25 Mar 2021 05:06 |
| Last Modified: | 25 Mar 2021 05:06 |
| URI: | https://repository.unja.ac.id/id/eprint/18822 |
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