UJI EFEK ANALGESIK RESIN JERNANG (Daemonorops draco (Willd.) Blume) TERHADAP MENCIT PUTIH JANTAN

Kasuari, Kemas Ryan (2022) UJI EFEK ANALGESIK RESIN JERNANG (Daemonorops draco (Willd.) Blume) TERHADAP MENCIT PUTIH JANTAN. S1 thesis, Universitas Jambi.

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Abstract

ABSTRACT Background : One of the plants that grows in the Jambi Province is Jernang. Jernang resin contains flavonoid compounds and triterpenoid compounds. Flavonoids are efficacious as analgesics by inhibiting the action of the cyclooxygenase enzyme by reducing the production of prostaglandins by arachidonic acid, thereby reducing pain. In the preliminary test, it was found that jernang resin had analgesic activity against white male mice at a dose of 500 mg. Methods : This study was experimental in a completely randomized design (CRD) using 5 treatment groups (K-, K+, P1, P2, P3). Each treatment consisted of 5 male mice with swiss webstar strain. This research was carried out in several stages, namely characterization of jernang resin (character of specific parameters and character of non-specific parameters), and testing the effect of giving jernang resin on the analgesic effect in mice using chemical stimulation and heat stimulation methods. The parameters observed were the number of wriggling and tail larvae of mice. Observational data were analyzed using One Way ANNOVA and continued with the Least Significant Different (LSD test). Results : Research results indicates that the resin extract of jernang contains alkaloids, flavonoids and terpenoids. Jernang resin extract has analgesic activity against white male mice. The effective dose that provides an analgesic effect is 750mg/KgBW. In the chemical stimulation method, the results of the % analgesic protection were 32.38% and the % effectiveness was 64.15%, while the % analgesic protection was 153.49% and the % effectiveness was 75.71% on the heat stimulation method. Conclusion : Jernang resin extract has analgesic activity against white male mice. The effective dose that provides an analgesic effect is 750mg/KgBW. Keywords : Analgesic, (Daemonorops draco (Willd.) Blume).

Type: Thesis (S1)
Subjects: L Education > L Education (General)
Depositing User: KASUARI
Date Deposited: 05 Dec 2022 01:31
Last Modified: 05 Dec 2022 01:31
URI: https://repository.unja.ac.id/id/eprint/38551

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