HUBUNGAN TINGKAT KEPARAHAN CEDERA OTAK DENGAN MARKER INFLAMASI C-REACTIVE PROTEIN (CRP) PADA PASIEN CEDERA OTAK TRAUMATIK DI RSUD RADEN MATTAHER

Astari, Kinanthi Prima (2022) HUBUNGAN TINGKAT KEPARAHAN CEDERA OTAK DENGAN MARKER INFLAMASI C-REACTIVE PROTEIN (CRP) PADA PASIEN CEDERA OTAK TRAUMATIK DI RSUD RADEN MATTAHER. S1 thesis, Universitas Jambi.

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Abstract

Latar Belakang Cedera otak traumatik (COT) merupakan penyebab utama disabilitas dan mortalitas di negara berkembang. Tubuh merespon adanya inflamasi saat terjadinya COT dengan mengeksresikan penanda inflamasi, C-Reactive Protein (CRP). Tujuan Mengetahui hubungan tingkat keparahan cedera otak dengan marker inflamasi C-Reactive Protein (CRP) pada pasien cedera otak traumatik di RSUD Raden Mattaher Metode Penelitian analitik observasional dengan rancangan penelitian cross sectional. Data diambil secara prospektif dengan metode purposive sampling pada pasien COT yang datang ke IGD RSUD Raden Mattaher periode Agustus-Oktober 2022 yang memenuhi kriteria inklusi dan eksklusi. Tingkat keparahan cedera otak ditentukan berdasarkan skor Glasglow Coma Scale dan pemeriksaan CRP menggunakan metode kualitatif. Hasil Didapatkan 25 subjek terdiri dari 11 pasien laki-laki dan 14 pasien perempuan dengan distribusi 17 (68%) pasien COT ringan, 4 (16%) pasien COT sedang, dan 4 (16%) pasien COT berat. Hasil pemeriksaan CRP menunjukkan hasil positif (68%) lebih banyak daripada hasil negatif (32%). Uji korelatif fisher exact test menunjukkan adanya hubungan bermakna antara variabel tingkat keparahan cedera otak dengan marker inflamasi c-reactive protein (p=0,026). Uji kompratif menunjukan tidak terdapat perbedaan bermakna antara kadar nilai CRP pada semua tingkat derajat keparahan cedera (p=0,70). Kesimpulan Terdapat hubungan bermakna antara tingkat keparahan cedera otak dengan marker inflamasi C-Reactive Protein (CRP) pada pasien cedera otak traumatik di RSUD Raden Mattaher Kata Kunci Cedera Otak Traumatik, C-Reactive Protein, Glassgow Coma Scale (GCS) Background Traumatic brain injury (TBI) is a major cause of disability and mortality in developing countries. The body responds to inflammation by excreting inflammatory markers, C-Reactive Protein (CRP) Objective To determine the relationship between the severity of brain injury and the inflammatory marker C-Reactive Protein (CRP) in traumatic brain injury patients at Raden Mattaher Hospital. Methods An observational analytic study with cross sectional design. Data were taken prospectively by purposive sampling method in TBI patients who came to the ER of RSUD Raden Mattaher for the period August- October 2022 that fulfilled inclusion and exclusion criteria. The severity of the brain injury was determined based on the Glasglow Coma Scale score and CRP examination using qualitative methods Results This study obtained 25 subjects consisting of 11 male patients and 14 female patients with a distribution of 17 (68%) patients with mild TBI, 4 (16%) patients with moderate TBI, and 4 (16%) patients with severe TBI. CRP examination results showed positive results (68%) more than negative results (32%). The correlative fisher exact test showed a significant relationship between the variable severity of brain injury and the inflammatory marker c-reactive protein (p=0.026). Comparative tests showed that there was no significant difference between the CRP values at all levels of injury severity (p=0.70). Conclusion There is a significant relationship between the severity of brain injury and the inflammatory marker C-Reactive Protein (CRP) in traumatic brain injury patients at Raden Mattaher Hospital Keywords Traumatic Brain Injury, C-Reactive Protein, Glassgow Coma Scale (GCS)

Type:	Thesis (S1)
Uncontrolled Keywords:	Cedera Otak Traumatik, C-Reactive Protein, Glassgow Coma Scale (GCS)
Subjects:	L Education > L Education (General) R Medicine > RD Surgery
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Kedokteran
Depositing User:	ASTARI
Date Deposited:	10 Jan 2023 07:41
Last Modified:	10 Jan 2023 07:41
URI:	https://repository.unja.ac.id/id/eprint/43793

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