Antifungal Activity of Neolignan Derivatives from Eusideroxylon zwageri Against Pathogenic Fungus Microsporum gypseum.

Khairunisa, Anis Yohana and Muhaimin, Muhaimin and Syamsurizal, Syamsurizal and Harizon, Harizon and Milanda, Tiana and Wicaksono, Imam Adi (2020) Antifungal Activity of Neolignan Derivatives from Eusideroxylon zwageri Against Pathogenic Fungus Microsporum gypseum. Pharmacognosy Magazine.

[img] Text
Antifungal Activity of Eusiderin Turnitin.pdf
Download (2MB)

Abstract

Introduction: Bulian wood (Eusideroxylon zwageri) known as iron wood. It was known as wood source which fungi and insect resistant. These effects were interconnected with secondary metabolites contained within. Methods: Eusideroxylon zwageri wood powder was macerated with methanol and fractinated with n-Hexane, dichloromethane, ethyl acetate. Eusiderin I and Compound B were isolated from n-hexane fraction, while Compound C were isolated from dichloromethane fraction. Eusiderin I, compound A and Compound B were characterized using melting point, UV spectroscopy and compared with previous data. Antifungal activity test was conducted with Microsporum gypseum using paper disc method. Results: A research on antifungal activity of Neolignan derivatives from Eusideroxylon zwageri against pathogenic fungus Microsporum gypseum had been carried out. Eusiderin I, Compound B and Compound C were isolated from wood of Eusideroxylon zwageri. All three compounds are white crystals with melting point in such 99-100 oC, 110-112 oC, 98-99 oC, respectively and UV spectrum data is similar to reference. The antifungal activity test of Eusiderin I, Compound B and Compound C from Bulian wood (Eusideroxylon zwageri) to phatogen fungus of Microsporum gypseum showed that with five different concentrations (5, 25, 50, 100 and 200 ppm), Eusiderin I was a potent antifungal because it had a strong activity in inhibiting the Microsporum gypseum growth. The 5 days incubation test result showed that 50 ppm Eusiderin I could inhibit the Microsporum gypseum colony growth. The 100 ppm Eusiderin I gave the most effective inhibition precentage because it could inhibit the Microsporum gypseum colony growth (= 93.9%). Conclusion: Based on this data, Eusiderin I can be indicated an antifungal candidate.

Type: Other
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Depositing User: Syamsurizal
Date Deposited: 04 May 2023 08:07
Last Modified: 04 May 2023 08:07
URI: https://repository.unja.ac.id/id/eprint/47901

Actions (login required)

View Item View Item
Repository Unja is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.