UJI EFEK ANTI INFLAMASI EKSTRAK ETANOL 25% DARI BIJI PINANG KUNING (Areca catechu L) TERHADAP SENDI LUTUT TIKUS PUTIH (Rattus Novergicus) MODEL OSTEOARTHRITIS

CHOIRURRAMADHANIAH, SHAFIRA (2023) UJI EFEK ANTI INFLAMASI EKSTRAK ETANOL 25% DARI BIJI PINANG KUNING (Areca catechu L) TERHADAP SENDI LUTUT TIKUS PUTIH (Rattus Novergicus) MODEL OSTEOARTHRITIS. S1 thesis, Kedokteran.

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Abstract

Background: Osteoarthritis (OA) is the most prevalent form of arthritis, particularly in Indonesia. Yellow pinang seeds (Areca Catechu L), which contain flavonoids have potential to provide anti-inflammatory effects such as NSAIDs and could be an alternative treatment for OA. Objective: The aim of this study was to demonstrate the potential anti-inflammatory effect of extract etanol 25% from yellow pinang nut (Areca catechu L) as a treatment method for rat knee joints in terms of joint swelling diameter and histopathological appearance in rat (Rattus novergicus) osteoarthritis model. Methodology: The research was conducted in January – April 2023 at the Biomedical Laboratory of the Faculty of Medicine by dividing 5 groups, namely the negative control group, positive control group, the concentration of extraxt etanol 25% of areca nut 2,5%; 5% and 10%. OA was induced using Monosodium Iodoacetate (MIA), and the average diameter of rat’s knee joint and the degree of inflammation were measured through histopathological examination. Results: The average diameter of rat’s knee joint decreased and there was a difference significant observed in the histopathological examination of the knee joint of rats between groups. Conclusion: The Yellow Pinang group at concentration 10% was more effective than the negative control group and other yellow pinang groups as an anti-inflammatory for early grade OA. . Keywords: Osteoarthritis, Yellow Areca, Histopathology. Latar belakang: Osteoartritis (OA) merupakan bentuk artritis yang paling banyak ditemukan, khususnya di Indonesia. Biji pinang kuning (Areca Catechu L) yang mengandung flavonoid berpotensi memberikan efek antiinflamasi seperti NSAID dan dapat menjadi alternatif pengobatan OA. Tujuan: Penelitian ini bertujuan untuk menunjukkan potensi efek antiinflamasi ekstrak etanol 25% dari buah pinang kuning (Areca catechu L) sebagai metode pengobatan sendi lutut tikus ditinjau dari diameter pembengkakan sendi dan gambaran histopatologis pada tikus ( Rattus novergicus) model osteoarthritis. Metodologi: Penelitian True Eksperimental dilakukan pada bulan Januari – April 2023 di Laboratorium Biomedik Fakultas Kedokteran dengan membagi 5 kelompok yaitu kelompok kontrol negatif, kelompok kontrol positif, konsentrasi ekstrak etanol 25% buah pinang 2,5%; 5% dan 10%. OA diinduksi menggunakan Monosodium Iodoacetate (MIA), dan diukur diameter rata-rata sendi lutut tikus serta derajat inflamasi melalui pemeriksaan histopatologi. Hasil: Rata-rata diameter sendi lutut tikus menurun selama 14 hari dan terdapat perbedaan bermakna pada pemeriksaan histopatologi sendi lutut tikus antar kelompok. Kesimpulan: Kelompok pinang kuning konsentrasi 10% lebih efektif dibandingkan dengan kelompok kontrol negatif dan kelompok pinang kuning lainnya sebagai antiinflamasi OA grade awal. Kata kunci: Osteoartritis, Pinang Kuning, Histopatologi.

Type:	Thesis (S1)
Subjects:	L Education > L Education (General)
Depositing User:	Choirurramadhaniah
Date Deposited:	11 Jul 2023 06:43
Last Modified:	11 Jul 2023 06:43
URI:	https://repository.unja.ac.id/id/eprint/52410

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