Validation UV Spectrophotometric Method to Determine Entrapment Efficiency of Ocular Polymeric Nanoparticle Levofloxacin Hemihydrate

Maharini, Indri and Martien, Ronny and Nugroho, Akhmad Kharis and Supanji, Supanji and Adhyatmika, Adhyatmika (2021) Validation UV Spectrophotometric Method to Determine Entrapment Efficiency of Ocular Polymeric Nanoparticle Levofloxacin Hemihydrate. Research Journal of Pharmacy and Technology, 14 (10). pp. 5479-5482. ISSN 0974-360X

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Abstract

Simple, easy, and economical UV spectrophotometric methods have been developed using simulated tear fluid (STF) solvent to determine levofloxacin hemihydrate (LEVH) levels in ocular nanoparticles, as indicated by the % entrapment efficiency. A maximum wavelength of levofloxacin at 288nm, with a 4.0-12.0µg/mL concentration, shows linear results with a correlation coefficient (r) of 0.9997 and an average % recovery of 99.920 –100.804%. The developed method is able to use for the analysis of levofloxacin hemihydrate in nanoparticle preparations.

Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Farmasi
Depositing User:	Maharini
Date Deposited:	17 Jan 2024 06:48
Last Modified:	17 Jan 2024 06:48
URI:	https://repository.unja.ac.id/id/eprint/59927

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