Maharini, Indri and Martien, Ronny and Nugroho, Akhmad Kharis and Supanji, Supanji and Adhyatmika, Adhyatmika (2021) Validation UV Spectrophotometric Method to Determine Entrapment Efficiency of Ocular Polymeric Nanoparticle Levofloxacin Hemihydrate. Research Journal of Pharmacy and Technology, 14 (10). pp. 5479-5482. ISSN 0974-360X
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Abstract
Simple, easy, and economical UV spectrophotometric methods have been developed using simulated tear fluid (STF) solvent to determine levofloxacin hemihydrate (LEVH) levels in ocular nanoparticles, as indicated by the % entrapment efficiency. A maximum wavelength of levofloxacin at 288nm, with a 4.0-12.0µg/mL concentration, shows linear results with a correlation coefficient (r) of 0.9997 and an average % recovery of 99.920 –100.804%. The developed method is able to use for the analysis of levofloxacin hemihydrate in nanoparticle preparations.
Type: | Article |
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Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Fakultas Kedokteran dan Ilmu Kesehatan > Farmasi |
Depositing User: | Maharini |
Date Deposited: | 17 Jan 2024 06:48 |
Last Modified: | 17 Jan 2024 06:48 |
URI: | https://repository.unja.ac.id/id/eprint/59927 |
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