KARAKTERISTIK KLINIKOPATOLOGI TUBERKULOSIS EKSTRAPULMONAL DI KOTA JAMBI

Mayangsari, Amytria Dewi and Fairuz, Fairuz and Suzan, Raihanah (2024) KARAKTERISTIK KLINIKOPATOLOGI TUBERKULOSIS EKSTRAPULMONAL DI KOTA JAMBI. S1 thesis, Universitas Jambi.

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Abstract

ABSTRAK Latar Belakang WHO melaporkan bahwa Indonesia berada di posisi kedua dengan jumlah penderita TB terbanyak di dunia setelah India. Tuberkulosis ekstrapulmonal (TBEP) adalah kasus tuberkulosis yang didiagnosis secara bakteriologis maupun klinis yang menginfeksi organ diluar paru. Penelitian ini bertujuan untuk mengetahui karakteristik klinikopatologi tuberkulosis ekstrapulmonal di Kota Jambi. Metode penelitian deskriptif dengan pendekatan retrospektif menggunakan data sekunder melalui rekam medik pasien yang telah terdiagnosis tuberkulosis ekstrapulmonal secara histopatologi pada tiga rumah sakit di Kota Jambi periode 2021 – 2023. Pengambilan data menggunakan teknik total sampling dengan ketentuan telah memenuhi kriteria eksklusi dan inklusi. Hasil Terdapat 102 pasien TBEP di Kota Jambi. Lokasi infeksi terbanyak pada KGB (49%), diikuti usus (24,5%), genitalia (9,8%), muskuloskeletal (8,8%), mammae (5,9%), saraf pusat dan telinga masing-masing (1%). Mayoritas terjadi pada perempuan (51%) dibanding laki-laki (49%). Kelompok usia mayoritas pada dewasa (49%), diikuti remaja (17,6%), balita dan pre lansia masing-masing (9,8%), lansia (8,8%) dan anak-anak (4,9%). Penyakit penyerta tidak banyak dijumpai, namun terdapat beberapa penyakit penyerta meliputi infeksi paru (4,9%), diabetes melitus (2,9%), dan malnutrisi (2%). Terdapat empat kelompok besar gambaran histopatologi yang dijumpai meliputi proliferasi sel limfosit (96,1%), sel epitheloid (99%), sel MGC/datia langhans (93,1%) dan nekrosis kaseosa (95,1%). Kesimpulan Tiga kasus TBEP terbanyak berdasarkan lokasi infeksi yang ditemukan di Kota Jambi meliputi KGB, usus, dan genitalia. Mayoritas terjadi pada perempuan dengan kelompok umur terbanyak pada dewasa dan remaja. Penyakit penyerta yang dijumpai meliputi infeksi paru, diabetes melitus, dan malnutrisi. Semua gambaran histopatologi banyak dijumpai disetiap kasus TBEP. Kata Kunci Tuberkulosis, Tuberkulosis Ekstrapulmonal, Gambaran Histopatologi ABSTRACT Background WHO reports that Indonesia has the second highest number of TB patients in the world after India. Extrapulmonary Tuberculosis (EPTB) is a case of tuberculosis diagnosed bacteriologically or clinically that infects organs outside the lungs. This study aims to determine the clinicopathological characteristics of extrapulmonary tuberculosis in Jambi. Methods Descriptive research with a retrospective approach using secondary data through medical records of patients who have been diagnosed with extrapulmonary tuberculosis by histopathologically in three hospitals in Jambi for the period 2021 - 2023. Data collection used a total sampling technique provided that it met the exclusion and inclusion criteria. Results There are 102 EPTB patients in Jambi. The most common location of infection was the lymph node (49%), followed by intestines (24.5%), genitalia (9.8%), musculoskeletal (8.8%), mammae (5.9%), central nervous system and ear each. (1%). The majority occured in females (51%) compared to males(49%). The age group was mostly adults (49%), followed by adolescents(17.6%), toddlers and pre-elderly (9.8%), elderly (8.8%) and children (4.9%). Comorbidities were not common, but there were several comorbidities including pulmonary infections (4.9%), diabetes mellitus (2.9%), and malnutrition (2%). There were four major groups of histopathologic features including lymphocyte cells proliferation (96.1%), epitheloid cells (99%), MGC/Datia Langhans cells (93.1%) and caseous necrosis (95.1%). Conclusion The three most common EPTB cases based on the location of infection found in Jambi include lymph nodes, intestine and genitalia. The majority occurred in females with the largest age groups in adults and adolescents. Comorbidities encountered included pulmonary infections, diabetes mellitus, and malnutrition. All histopathologic features were found in every EPTB case. Keywords Tuberculosis, Extrapulmonary Tuberculosis, Histopathologic Features

Type:	Thesis (S1)
Subjects:	L Education > L Education (General) R Medicine > RB Pathology
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Kedokteran
Depositing User:	MAYANGSARI
Date Deposited:	08 May 2024 02:23
Last Modified:	09 Jul 2024 06:07
URI:	https://repository.unja.ac.id/id/eprint/63353

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