The Optimization of Sodium Alginate and Propylene Glycol in Antioxidant Gel Formulation Containing White Turmeric Extract (Curcuma zedoaria)

Lusiana, Alfitri and yuliawati, yuliawati and Pratiwi, Puspa Dwi and Astuti, Novia Tri (2025) The Optimization of Sodium Alginate and Propylene Glycol in Antioxidant Gel Formulation Containing White Turmeric Extract (Curcuma zedoaria). Indonesian Journal of Pharma Science (IJPS), 7 (1). pp. 31-41. ISSN 26856549

Text IJPS PUBLISH .pdf - Published Version Download (515kB)

Abstract

Temu putih rhizome (Curcuma zedoaria) has an antioxidant activity. This study aimed to optimize the combination of sodium alginate and propylene glycol in gel formulations and compare the antioxidant activity of the ethanol extract and gel form. Gel formulations were developed using a Simplex Lattice Design, with varying ratios of sodium alginate (A) and propylene glycol (B): F1 (3% A:8% B), F2 (2% A:9% B), F3 (2.5% A:8.5% B), F4 (1% A:10% B), and F5 (1.5% A:9.5% B). Physical properties were evaluated to determine the optimal formula using Design Expert version 13 and one-sample t-test. Antioxidant activity was assessed via the DPPH method. Results showed that sodium alginate increased viscosity and adhesiveness, while propylene glycol improved spreadability and pH. The optimal formulation contained 2.98% sodium alginate and 8% propylene glycol. The ethanol extract and gel showed IC50 values of 50.169 ppm and 67.675 ppm, respectively.

Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Farmasi
Depositing User:	Novia Tri Astuti
Date Deposited:	30 Aug 2025 04:04
Last Modified:	30 Aug 2025 04:04
URI:	https://repository.unja.ac.id/id/eprint/85527

Actions (login required)

View Item