turnitin :Toxicity Test of Muara Jambi Areca Nut (Areca Catechu L.) Extract on Rat Bone Marrow-derived Mesenchymal Stem Cells

humaryanto, humaryanto and Ayudia, Esa Indah and Muhaimin, Muhaimin and maria, silmi (2021) turnitin :Toxicity Test of Muara Jambi Areca Nut (Areca Catechu L.) Extract on Rat Bone Marrow-derived Mesenchymal Stem Cells. ATLANTIS PRESS, 205. pp. 273-280. ISSN 2352-5398

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Abstract

Osteoarthritis (OA) is a joint inflammation process that happens when chondrocytes failure in maintaining the balance between degradation and extracellular matrix synthesis. Thus, it results in changes in the diameter and orientation of collagen fibers that change cartilage biomechanics and make joint cartilage lose its unique compressibility properties. This case is increasing every year globally, including Indonesia, but no drug could effectively treat this disease until recently. The use of areca nut as traditional anti-inflammatory drugs has long been known, but the scientific evidence is lacking. This study aims to develop a simple in vitro OA model that is useful for predicting the ability of drugs to reduce cartilage hypertrophy by using the seeds of areca nut (Areca catechu L). In this study, the extraction and fractionation of areca nut (Areca catechu L) were carried out to obtain the active substances in the form of ethanol, alkaloid, and flavonoid compounds. Acute toxicity assessment using the Methyl thiazole tetrazolium (MTT) method resulted in LD50 487.94 ppm. This shows that the Areca nut (Areca catechu L.) isolate is not toxic; therefore, it can be given as an alternative medicine for humans.

Type:	Article
Subjects:	A General Works > AC Collections. Series. Collected works Universitas Jambi (UNJA) > Fakultas Kedokteran dan Ilmu Kesehatan > A General Works > AC Collections. Series. Collected works
Divisions:	Library of Congress Subject Areas > A General Works > AC Collections. Series. Collected works Fakultas Kedokteran dan Ilmu Kesehatan > A General Works > AC Collections. Series. Collected works
Depositing User:	Humaryanto
Date Deposited:	05 May 2023 03:01
Last Modified:	05 May 2023 03:01
URI:	https://repository.unja.ac.id/id/eprint/47973

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