PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SIRSAK (Anonna Muricata) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL PADA TIKUS (Rattus Novergicus) HIPERKOLESTEROLEMIA

Hidayat, Husnan (2025) PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SIRSAK (Anonna Muricata) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL PADA TIKUS (Rattus Novergicus) HIPERKOLESTEROLEMIA. S1 thesis, Kedokteran.

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Abstract

ABSTRACT Background: According to the 2018 Basic Health Research Data, the prevalence of hypercholesterolemia in Indonesia is still very high. Soursop leaves contain active substances flavonoids, saponins, and tannins which are believed to be able to be used to lower blood cholesterol levels. The purpose of this study was to determine the effect of giving ethanol extract of soursop leaves (Anonna muricata.) On cholesterol levels of white rats (Rattus novergicus) Hypercholesterolemia. Method: This study used a quantitative analysis research type True Experimental using the Randomized Pre Test- Post test Control Group Design using White Rats (Rattus Norvegicus) strain Sprague Dawley as experimental animals aged 3-6 months, weighing 200-250 grams which were made into 6 groups, namely the basal group, positive treatment group, B, C, D and E were given a high-fat diet, and ethanol extract of soursop leaves at a dose of 100 mg / ml of young and old soursop leaves, 200 mg / ml of young and old. The treatment was carried out for 14 days. Blood cholesterol levels were examined 3 times, namely at the beginning, after induction of a high-fat diet and after administration of the extract. Data were analyzed statistically using the One-way ANOVA test. Results: From the results of the paired t-test, there was a decrease in blood cholesterol levels in the treatment group (p<0.05). The most significant reduction in cholesterol levels was in treatment group D with 200 mg/ml ethanol extract of old soursop leaves. Conclusion: From the research results, it was concluded that administration of ethanol extract of soursop leaves (Anonna muricata.) had an effect on reducing blood cholesterol levels in white rats (Rattus novergicus) of the Sprague Dawley strain. Keywords: Soursop leaves (Anonna muricata.), Hypercholesterolemia, Decrease in blood cholesterol levels, white rats (Rattus novergicus).

Type: Thesis (S1)
Subjects: R Medicine > RB Pathology
Depositing User: Hidayat
Date Deposited: 14 Jan 2025 06:50
Last Modified: 14 Jan 2025 06:50
URI: https://repository.unja.ac.id/id/eprint/74536

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