The optimization of gelling agent and humectant in antioxidant gel formula with Carica papayaLinn. leaf extract based on simplex lattice design method

Pratiwi, Puspa Dwi and Gusti, Diah and Anggraini, Resti Indah (2023) The optimization of gelling agent and humectant in antioxidant gel formula with Carica papayaLinn. leaf extract based on simplex lattice design method. JOURNAL OF PHARMACEUTICAL AND SCIENCES, 1 (1). pp. 283-291. ISSN 26563088

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Abstract

Papaya leaf (Carica papayaL.) have very strong antioxidantactivity with IC50value 21.08 ppm. C. papayaL.leafcan be formulated in gel preparation. The physical properties of gel and its effectiveness as an antioxidant can be affected by excipients, so it is necessary to optimize the formula. The aims of this research were to find the concentration of sodium carboxy methyl cellulose (Na-CMC) as gelling agent and glycerin as humectant to getoptimal formulawith the best physical propertiesand measure its antioxidant activity. Simplex lattice design (SLD) method was chosen for formula optimization with Na-CMC range 0.5-4% and glycerin 10-13.5%. The optimal formula was determined based on pH value, spreadability, stickiness and viscosity then determined for antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results of this research wereoptimal formula with Na-CMC concentration 1.853% and glycerin 12.147%. The antioxidant activity of the optimal formula was decreased from the extract activity, with an IC50value 21.08 ppm (very strong) to 61.70 ppm (strong). It can be concluded that the optimal formula for papaya leaf (C. papayaL.) extract gel preparation can be obtained withcombination of Na-CMC and glycerin using the SLD method with strong antioxidant value

Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Farmasi
Depositing User:	Puspa Dwi Pratiwi
Date Deposited:	25 Feb 2025 02:02
Last Modified:	25 Feb 2025 02:02
URI:	https://repository.unja.ac.id/id/eprint/75623

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