HUBUNGAN POLIMORFISME GEN MELANOCORTIN 4 RECEPTOR (MC4R) DENGAN LEMAK VISERAL TUBUH

Juhari, Alya Dwiva (2025) HUBUNGAN POLIMORFISME GEN MELANOCORTIN 4 RECEPTOR (MC4R) DENGAN LEMAK VISERAL TUBUH. S1 thesis, Universitas Jambi.

	Text SKRIPSI FULL TEXT.pdf Restricted to Repository staff only Download (3MB)
	Text Cover.pdf Download (201kB)
	Text ABSTRAK.pdf Download (240kB)
	Text BAB I.pdf Download (271kB)
	Text BAB V.pdf Download (126kB)
	Text DAFTAR PUSTAKA.pdf Download (151kB)
	Text HALAMAN PENGESAHAN.pdf Download (548kB)

Abstract

ABSTRACT Background: Central obesity, characterized by increased visceral fat accumulation, is a risk factor for metabolic diseases. Its prevalence has been rising in recent years. One of the genetic factors involved is the Melanocortin 4 Receptor (MC4R) gene. The relationship between the MC4R gene and visceral fat is still under-researched. This study aims to analyze the association between the MC4R rs17782313 polymorphism and visceral fat levels in the adult population of Jambi. Methods: This study used an unmatched case-control design involving 112 subjects. Genotyping was performed using the Tetra-ARMS-PCR method, while visceral fat levels were measured using Bioelectrical Impedance Analysis (BIA). Data analysis was conducted using chi-square tests to determine the association between the MC4R polymorphism and visceral fat levels. Results: Subjects with high visceral fat had an older average age (38.35 ± 10.41 years), were predominantly male (66%), and had larger waist circumferences (98.36 ± 7.76 cm) compared to the normal group (p<0.05). Genetic analysis revealed that the majority of genotypes were TT (75.9%), followed by TC (20.5%) and CC (3.6%). No significant association was found between the MC4R rs17782313 polymorphism and visceral fat distribution (p>0.05). Conclusion: There were significant differences in age, sex, and waist circumference between the high and normal visceral fat groups. However, the MC4R rs17782313 polymorphism did not significantly correlate with visceral fat levels. Keywords: MC4R polymorphism, Tetra-ARMS-PCR, visceral fat.   ABSTRAK Latar Belakang: Obesitas sentral ditandai dengan akumulasi lemak viseral meningkat merupakan faktor risiko penyakit metabolik. Prevalensinya meningkat dalam beberapa tahun terakhir. Salah satu faktor genetik yang berperan adalah gen Melanocortin 4 Receptor (MC4R). Hubungan gen MC4R dengan lemak viseral masih terbatas diteliti. Penelitian ini bertujuan untuk menganalisis hubungan polimorfisme gen MC4R rs17782313 dengan kadar lemak viseral pada populasi dewasa di Jambi. Metode: Penelitian ini menggunakan desain unmatched case-control dengan melibatkan 112 subjek. Genotyping dilakukan menggunakan metode Tetra-ARMS-PCR, sedangkan kadar lemak viseral diukur dengan Bioelectrical Impedance Analysis (BIA). Analisis data dilakukan menggunakan uji chi-square untuk mengetahui hubungan antara polimorfisme gen MC4R dengan kadar lemak viseral. Hasil: Subjek dengan lemak viseral tinggi memiliki rata-rata usia lebih tua (38,35 ± 10,41 tahun), mayoritas laki-laki (66%) dan lingkar pinggang (98,36 ± 7,76 cm) lebih besar dibandingkan dengan subjek kelompok normal (p<0,05). Analisis genetik menunjukkan mayoritas genotipe adalah TT (75,9%), diikuti TC (20,5%) dan CC (3,6%). Tidak ditemukan hubungan yang signifikan antara polimorfisme MC4R rs17782313 dengan distribusi lemak viseral (p>0,05). Kesimpulan: Terdapat perbedaan bermakna dalam karakteristik usia, jenis kelamin, dan lingkar pinggang antara kelompok lemak viseral tinggi dan normal. Namun, polimorfisme gen MC4R rs17782313 tidak menunjukkan hubungan signifikan dengan kadar lemak viseral. Kata Kunci: Lemak viseral, polimorfisme MC4R, Tetra ARMS-PCR

Type:	Thesis (S1)
Uncontrolled Keywords:	Lemak viseral, polimorfisme MC4R, Tetra ARMS-PCR
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Kedokteran
Depositing User:	ALYA DWIVA JUHARI
Date Deposited:	07 Mar 2025 03:46
Last Modified:	07 Mar 2025 03:46
URI:	https://repository.unja.ac.id/id/eprint/75890

Actions (login required)

View Item