PENGARUH INFEKSI ESCHERICHIA COLI TERHADAP KADAR KOLAGEN TIPE 1 PADA PLASENTA MENCIT BALB/C MODEL PREMATUR

alifia, khalisha salsabila (2025) PENGARUH INFEKSI ESCHERICHIA COLI TERHADAP KADAR KOLAGEN TIPE 1 PADA PLASENTA MENCIT BALB/C MODEL PREMATUR. S1 thesis, universitas jambi.

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Abstract

Background: Preterm birth is a major cause of neonatal morbidity and mortality. One contributing factor is intrauterine infection by Escherichia coli, which triggers inflammation and degradation of extracellular matrix components such as type 1 collagen. This collagen is essential for maintaining the structural integrity of placental tissue. Objective: To determine the effect of Escherichia coli infection on type 1 collagen levels in the placenta of BALB/c mice as a preterm birth model. Methods: This was a cross-sectional analytical observational study using secondary data from 28 pregnant BALB/c mice divided into four groups: N1, N2, P1, and P2. Escherichia coli was administered on day 15 of gestation. Type 1 collagen levels were measured using ELISA. Data analysis included the Shapiro- Wilk test, independent t-test, and ANOVA. Results: A significant decrease in type 1 collagen levels was observed in the treatment groups infected with Escherichia coli compared to controls (p<0.05). Group P2 exhibited the most substantial reduction in collagen levels. Conclusion: Escherichia coli infection significantly reduces type 1 collagen levels in the placenta of BALB/c mice, potentially contributing to the mechanism of preterm labor. Keywords: Escherichia coli, type 1 collagen, placenta, BALB/c mice, preterm birth

Type:	Thesis (S1)
Uncontrolled Keywords:	Escherichia coli, type 1 collagen, placenta, BALB/c mice, preterm birth
Subjects:	L Education > L Education (General) R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics
Divisions:	Fakultas Kedokteran dan Ilmu Kesehatan > Kedokteran
Depositing User:	Khalisha Salsabila Alifia
Date Deposited:	10 Jul 2025 04:07
Last Modified:	02 Aug 2025 04:12
URI:	https://repository.unja.ac.id/id/eprint/82794

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